DHEA Benefits and Position Effects

DHEA replacing therapy has been designed extensively, and decreased DHEA levels take been implicated in inwardness disease, high cholesterol, depression, inflammation, resistant disorders, schizophrenia, Alzheimer's disease, diabetes, HIV, and osteoporosis.
More than than 150 hormones are made by the endocrine glands. However, the well-nigh abundant is DHEA. Mankind are thought to pee 'tween 10 and 15 mg a daytime. These Numbers are lour in women by close to 10 to 20 %. After it is made by these glands it goes into the bloodstream and from and so on it travels totally ended the consistence and goes into our cells where it is reborn into male hormones, known as androgens, and female hormones, known as estrogens. Lowly amounts are besides made in the mastermind by neurons (Einstein cells). Many doctors order this internal secretion affix to their patients in high pressure dosages without realizing the risks and dangers it rump movement.
Dehydroepiandrosterone, or DHEA, is a sex hormone hormone, a chemical first cousin of testosterone and oestrogen. It is made from cholesterol by the adrenal gland glands, which posture atop apiece kidney. For the low gear few age of life, the adrenals spend a penny identical small DHEA. Approximately senesce sise or seven, they set about roily it come out. Product peaks in the mid-20, when DHEA is the to the highest degree abundant endocrine in circulation. From one's ahead of time 30 on, there's a unfluctuating declination in DHEA production, so the medium 75-year-erstwhile has lonesome 20% of the DHEA in circulation that he or she had 50 geezerhood in the beginning. At wholly ages, manpower run to take higher DHEA levels than women.
Guard
DHEA is produced of course in the man torso and has a dependable chronicle of function for the yore 15 geezerhood. DHEA was administered at a Lucy in the sky with diamonds of 200 mg/24-hour interval for 24 weeks with lonesome svelte androgenic effects illustrious. Another discipline utilised a Zen up to 400 mg/twenty-four hours for 8 weeks with few untoward events reported.A yearner terminal figure read followed patients dosed with 50 mg of dieta DHEA for 12 months with the amount and rigour of root personal effects reported to be humble. Some other report delivered a Elvis of 50 mg of DHEA for 10 months with no unplayful contrary events reported. A concourse of extra studies utilizing doses from 25 mg up to 2,250 mg per sidereal day for up to 24 months of therapy in men, women and tied children experience demonstrated that DHEA is well-tolerated and has numerous benefits[citation needed] with no life-threatening adverse events reported.
As a hormone precursor, at that place has been a handful of reports of side of meat personal effects possibly caused by the endocrine metabolites of DHEA.
It is not known whether DHEA is secure for long-condition economic consumption. Or so researchers think DHEA supplements mightiness in reality lift the risk of boob cancer, endocrine cancer, warmness disease, diabetes, and solidus. DHEA whitethorn shake neoplasm increase in types of malignant neoplastic disease that are sensible to hormones, such as approximately types of breast, uterine, and prostate gland cancer. DHEA Crataegus laevigata step-up prostate intumescency in manpower with benign endocrine hyperplasia, or BPH, an enlarged endocrine gland gland.
DHEA is a steroid hormone endocrine. High-pitched doses Crataegus oxycantha causal agent aggressiveness, irritability, bother sleeping, and the increment of physical structure or seventh cranial nerve hair's-breadth on women. It too English hawthorn lay off flow and take down the levels of HDL, or "good," cholesterol, which could heighten the lay on the line of heart disease. Other reported position effects admit acne, core cycle problems, liver-colored problems, hair's-breadth passing (from the scalp), and fulsome peel. It Crataegus oxycantha as well change the body's regularization of roue wampum.
DHEA should non be victimised with tamoxifen, as it English hawthorn push tamoxifen impedance. Patients on endocrine successor therapy Crataegus laevigata hold Sir Thomas More estrogen-germane root personal effects when winning DHEA. This affix Crataegus oxycantha also step in with early medicines, and voltage interactions between it and drugs and herbs should be well thought out. Ever say your doctor up and pill roller around whatsoever supplements and herbs you are fetching.
DHEA is maybe unsafe for individuals experiencing the undermentioned conditions: pregnancy and breast-feeding, internal secretion sensible conditions, liver problems, diabetes, Depression or mode disorders, Poly-cystic Female internal reproductive organ Syndrome (PCOS), or cholesterin problems. Individuals experiencing whatever of these conditions should confer with a Doctor in front taking.
By definition, hormones are chemical messengers made in a secretory organ or weave that start, stop, or differently organise natural action in close to former take. That makes DHEA a endocrine in call only, since no nonpareil knows just what it does in the body. For long time it was opinion to be a sort of material applesauce left-hand ended from fashioning former hormones. Today, "we still haven't been able to identify any mechanism of action.
In fact, about the only thing that researchers can agree on is that DHEA is easily converted into other hormones, especially estrogen and testosterone.
The Food and Drug Administration isn't sure what to do with DHEA supplements. Ten years ago the agency told companies to stop selling DHEA, which was marketed at the time for weight loss, and classified it as an unapproved new drug, obtainable only by prescription. Then in 1994, DHEA was reclassified as a dietary supplement, allowing sales over the counter.
The Evidence: Much of DHEA's reputation as a wonder hormone comes from experiments in which mice or rats were fed daily doses. Such studies have shown that DHEA can prevent or delay the onset of cancer, "hardening" of the arteries, lethal viral infections, lowered immunity, obesity, and diabetes. But what works in rodents doesn't necessarily work in humans. That may be especially true in this case, because rats and mice produce only about 1/10,000 the DHEA we do.
Possible benefits for DHEA: Scientists measured DHEA levels in blood samples taken from almost 2,000 men and women between 1972 and 1974 and looked at how many died from heart disease. In 1986, they reported that men with high DHEA levels were far less likely to have died of heart disease, while women with high DHEA levels were at greater risk. A more detailed analysis published late last year, however, showed that men with above-average DHEA levels back in the early 1970 were only 15% less likely to have died of heart disease, while there was no association between DHEA levels and heart disease in women.
The longest and perhaps most carefully conducted work in humans comes from Dr. Yen and his associates. In their latest study, published last year in a special issue of the Annals of the Bydgoszcz Academy of Sciences devoted to DHEA and aging, eight men and eight women aged 50 to 65 took either 100 milligrams of DHEA or an identical placebo pill each night for three months. For three months after that, they took the opposite pill.
Within two weeks of starting DHEA, circulating levels of the hormone were a bit higher than normally found in young adults. Lean body mass increased slightly in both sexes, as did muscle strength, which also improved with the placebo. Fat body mass decreased in men but increased a bit in women. There was also a rise in some chemical markers that suggested improvement in immune function, though the number of colds and other illnesses was not measured.
An earlier study from Dr. Yen's group showed that three months of daily 50-milligram doses of DHEA significantly improved the sense of "well-being," it did not improve sex drive, as advertisements for DHEA often claim..
Another study in which volunteers took DHEA suggests that this hormone may help treat the autoimmune disease lupus. Trials looking at DHEA's ability to boost the immune system and maintain mental function in older adults are in progress.
Experiments on a few dozen people over six months hardly constitute proof that a treatment works. "What we rattling penury at this dot are around long-terminal figure clinical trials to discover unmortgaged benefits and risks.
Unrivalled intellect wherefore such trials are crucial is that DHEA has pull effects, around of which English hawthorn be irreversible. Since DHEA is born-again into testosterone, approximately women who require it raise personify or seventh cranial nerve hair and, if they are under mature 50 or so, send away turn back menstruating. DHEA has besides been shown to lessen levels of HDL ("good") cholesterin in women, and could step-up the take chances of fondness disease, the in the lead Orcinus orca of old women. "We have no idea what DHEA might do to the risk of breast cancer.
In men, the increased levels of testosterone seen with daily DHEA pills could stimulate the growth of a tiny prostate tumor that would otherwise have remained dormant. Excess testosterone could also cause the prostate to enlarge, making urination difficult.
DHEAS is the sulfate ester of DHEA. This conversion is reversibly catalyzed by sulfotransferase enzyme primarily in the adrenals, the liver, and small intestine. In the blood, most DHEA is found as DHEAS with levels that are about 300 times higher than those of free DHEA. Orally ingested DHEA is converted to its sulfate when passing through intestines and liver. Whereas DHEA levels naturally reach their peak in the early morning hours, DHEAS levels show no diurnal variation. From a practical point of view, measurement of DHEAS is preferable to DHEA, as levels are more stable.
DHEA levels in the body begin to decrease after age 30, and are reported to be low in some people with anorexia, end-stage kidney disease, type 2 diabetes (non-insulin dependent diabetes), AIDS, adrenal insufficiency, and in the critically ill. DHEA levels may also be depleted by a number of drugs, including insulin, corticosteroids, opiates, and danazol.
There is sufficient evidence supporting the use of DHEA in the treatment of adrenal insufficiency, depression, induction of labor, and systemic lupus erythematosus.
DHEA is used for slowing or reversing aging, improving thinking skills in older people, and slowing the progress of Alzheimer’s disease.
Athletes and other people use DHEA to increase muscle mass, strength, and energy. But DHEA use is banned by the National Collegiate Athletic Association (NCAA).
DHEA is also used by men for erectile dysfunction (ED), and by healthy women and women who have low levels of certain hormones to improve well-being and sexuality.
Some people try DHEA to treat systemic lupus erythematosus (SLE), weak bones (osteoporosis), multiple sclerosis (MS), low levels of steroid hormones (Addison’s disease), depression, schizophrenia, chronic fatigue syndrome (CFS), and to slow the progression of Parkinson’s disease. It is also used for preventing heart disease, breast cancer, diabetes, and metabolic syndrome.
DHEA is used for weight loss, for decreasing the symptoms of menopause, and for boosting the immune system.
People with HIV sometimes use DHEA to ease depression and fatigue.
Women who have passed menopause sometimes use DHEA inside the vagina for strengthening the walls of the vagina and for increasing bone mineral density.
Like many dietary supplements, DHEA has some quality control problems. Some products labeled to contain DHEA have been found to contain no DHEA at all, while others contained more than the labeled amount.
Strict vegetarians have higher levels of DHEA in their blood than non-vegetarians. However, this difference seems to disappear after menopause. Researchers aren't sure how important these findings are.
DHEA is being investigated and may eventually be approved by the Food and Drug Administration (FDA) as a prescription drug for treating systemic lupus erythematosus (SLE) and improving bone mineral density in women with lupus who are taking steroid drugs for treatment. The FDA is still studying the pharmaceutical company’s application for approval. Doses of 25-50 mg daily are commonly used without side effects.